Effects of topical anandamides on intraocular pressure in normotensive rabbits

Life Sci. 1996;58(21):1849-60. doi: 10.1016/0024-3205(96)00169-5.


A series of anandamide-type compounds were synthesized and studied for their effect on the intraocular pressure (IOP) of normotensive pigmented rabbits. Each test compound was dissolved in an aqueous 2-hydroxypropyl-beta-cyclodextrin solution and administered (31.25 - 62.5 micrograms) unilaterally to the eye. The most promising anandamides caused a statistically significant reduction of IOP in treated eyes, usually preceded by an initial transient elevation of IOP, compared to saline controls. In the contralateral untreated eyes, only a marginal or short hypotensive response was observed. Indomethacin pre-treatment (12.5 mg, s.c.) eliminated the IOP response to administered anandamides and arachidonic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Cannabinoids / administration & dosage
  • Cannabinoids / chemistry
  • Cannabinoids / pharmacology*
  • Female
  • Indomethacin / pharmacology
  • Intraocular Pressure / drug effects*
  • Male
  • Rabbits
  • Structure-Activity Relationship


  • Cannabinoids
  • Indomethacin