The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease

Metabolism. 1996 Jun;45(6):669-72. doi: 10.1016/s0026-0495(96)90129-8.


The insulin resistance syndrome has recently been implicated in the etiology of coronary heart disease, with a possible metabolic defect at the level of the adipocyte. We report the effects of a low- versus high-glycemic-index (LGI and HGI, respectively) diet on insulin and glucose response as assessed by oral glucose tolerance test (OGTT) and insulin-stimulated glucose uptake in isolated adipocytes in a group of 32 patients with advanced coronary heart disease. The area under the insulin curve following OGTT was significantly reduced after 4 weeks in the LGI group (P < .03), but not in the HGI group. Insulin-stimulated glucose uptake in isolated adipocytes harvested from a presternal fat biopsy was significantly greater following the LGI diet (P < .05). This study demonstrates that simple short-term dietary measures can improve insulin sensitivity in patients with coronary heart disease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / metabolism
  • Blood Glucose / metabolism*
  • Coronary Disease / diet therapy*
  • Coronary Disease / metabolism
  • Dietary Carbohydrates / administration & dosage*
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance
  • Male
  • Middle Aged


  • Blood Glucose
  • Dietary Carbohydrates
  • Insulin