Molecular chaperones in cellular protein folding

Nature. 1996 Jun 13;381(6583):571-9. doi: 10.1038/381571a0.


The folding of many newly synthesized proteins in the cell depends on a set of conserved proteins known as molecular chaperones. These prevent the formation of misfolded protein structures, both under normal conditions and when cells are exposed to stresses such as high temperature. Significant progress has been made in the understanding of the ATP-dependent mechanisms used by the Hsp70 and chaperonin families of molecular chaperones, which can cooperate to assist in folding new polypeptide chains.

Publication types

  • Review

MeSH terms

  • Animals
  • Chaperonins / physiology*
  • HSP70 Heat-Shock Proteins / physiology
  • Humans
  • Protein Folding*


  • HSP70 Heat-Shock Proteins
  • Chaperonins