Fusion of the EWS and CHOP genes in myxoid liposarcoma

Oncogene. 1996 Feb 1;12(3):489-94.


The translocation t(12;16)(q13;p11), which cytogenetically characterizes myxoid liposarcomas (MLS), results in a fusion of the CHOP gene in 12q13 and the FUS gene in 16p11, creating a chimeric FUS/CHOP gene. We have identified two cases of MLS with translocations giving rise to recombination between 12q13 and 22q12. The result was a fusion of the N-terminal part of the EWS gene in 22q12, involved in a number of mesenchymal tumor types, with the CHOP gene and the creation of an EWS/CHOP chimeric gene. The presence of the EWS/CHOP chimeric gene in MLS shows that (i) the N-terminal part of FUS may be replaced by the N-terminal part of EWS in a CHOP fusion oncoprotein (ii) the two N-terminal parts, when fused to certain transcription factors, have a common or very similar oncogenic potential and (iii) the tumorigenic process in MLS and the morphogenetically distinctly different EWS-associated tumor types may be related.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • CCAAT-Enhancer-Binding Proteins*
  • Cell Line
  • Chimera
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Chromosomes, Human, Pair 16*
  • DNA Primers
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / genetics*
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics
  • Liposarcoma, Myxoid / genetics*
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Neoplasm Proteins / biosynthesis
  • Neoplasm Proteins / genetics
  • Nuclear Proteins / biosynthesis
  • Nuclear Proteins / genetics
  • Polymerase Chain Reaction
  • RNA-Binding Protein EWS
  • RNA-Binding Protein FUS
  • Restriction Mapping
  • Ribonucleoproteins / biosynthesis
  • Ribonucleoproteins / genetics*
  • Sarcoma / genetics
  • Transcription Factor CHOP
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Translocation, Genetic*


  • CCAAT-Enhancer-Binding Proteins
  • DDIT3 protein, human
  • DNA Primers
  • DNA-Binding Proteins
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Neoplasm Proteins
  • Nuclear Proteins
  • RNA-Binding Protein EWS
  • RNA-Binding Protein FUS
  • Ribonucleoproteins
  • Transcription Factors
  • Transcription Factor CHOP

Associated data

  • GENBANK/X92120