A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

J Antibiot (Tokyo). 1977 Apr;30(4):275-82. doi: 10.7164/antibiotics.30.275.


AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.

MeSH terms

  • Alkaloids / biosynthesis
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Fermentation
  • Lethal Dose 50
  • Mice
  • Microbial Sensitivity Tests
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Time Factors


  • Alkaloids