Vascular endothelial growth factor B, a novel growth factor for endothelial cells

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2576-81. doi: 10.1073/pnas.93.6.2576.

Abstract

We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cells, Cultured
  • Cloning, Molecular
  • Endothelial Growth Factors / genetics
  • Endothelial Growth Factors / physiology*
  • Endothelium, Vascular / cytology*
  • Gene Expression Regulation
  • Humans
  • Mice
  • Molecular Sequence Data
  • Peptides / immunology
  • RNA, Messenger / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Vascular Endothelial Growth Factor B

Substances

  • Endothelial Growth Factors
  • Peptides
  • RNA, Messenger
  • Vascular Endothelial Growth Factor B

Associated data

  • GENBANK/U48800
  • GENBANK/U52819
  • GENBANK/U52820