Metastatic prostate cancer: initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose

Radiology. 1996 Jun;199(3):751-6. doi: 10.1148/radiology.199.3.8638000.


Purpose: To evaluate the accuracy of positron emission tomography (PET) with 2-deoxy-2-[fluorine-18] fluoro-D-glucose (FDG) in the detection of osseous and soft-tissue metastases of prostate cancer.

Materials and methods: Thirty-four patients (mean age, 71 years) with biopsy-proved prostate cancer and known or suspected metastatic disease were examined. Blinded interpretation of the PET images was compared with bone scan, CT, and clinical follow-up findings.

Results: In 202 untreated osseous metastases in 22 patients, the sensitivity of FDG PET was 65% (131 of 202 metastases), with a positive predictive value of 98% (131 of 133 positive findings). The estimated standardized uptake value in metastases was 2.1-5.7. Soft-tissue metastases to the lymph nodes or liver were identified, but evaluation of pelvic lymph node metastases was severely limited because of bladder tracer activity.

Conclusion: FDG PET can help identify osseous and soft-tissue metastases of prostate cancer with a high positive predictive value but is less sensitive than bone scintigraphy in the identification of osseous metastases.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / secondary*
  • Bone and Bones / diagnostic imaging
  • Contrast Media*
  • Deoxyglucose / analogs & derivatives*
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Prostatic Neoplasms / diagnostic imaging*
  • Soft Tissue Neoplasms / diagnostic imaging*
  • Soft Tissue Neoplasms / secondary*
  • Tomography, Emission-Computed / instrumentation
  • Tomography, Emission-Computed / methods*
  • Tomography, X-Ray Computed


  • Contrast Media
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Deoxyglucose