GABAC receptors

Trends Neurosci. 1995 Dec;18(12):515-9. doi: 10.1016/0166-2236(95)98370-e.


gamma-Aminobutyric acid (GABA) is an important neurotransmitter that mediates inhibition in the vertebrate CNS. Until recently, two receptor subtypes were known: bicuculline-sensitive GABAA and baclofen-sensitive GABAB receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor, which is distinct pharmacologically from GABAA and GABAB receptors and is found predominantly in the vertebrate retina. These novel GABAC receptors are Cl- pores. They are insensitive to drugs that modulate GABAA and GABAB receptors and are activated selectively by cis-4-aminoacrotonic acid.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Receptors, GABA / drug effects
  • Receptors, GABA / physiology*


  • GABA-C receptor
  • Receptors, GABA