Reduced trabecular meshwork height in juvenile primary open-angle glaucoma

Arch Ophthalmol. 1996 Jun;114(6):660-3. doi: 10.1001/archopht.1996.01100130652003.


Objective: To compare trabecular meshwork height in a series of patients with juvenile primary open-angle glaucoma (JPOAG) with that in normal control patients.

Methods: Ultrasound biomicroscopy and A-scan biometry were performed on 16 eyes with JPOAG and 24 normal eyes. A radial, perpendicular image in the horizontal temporal meridian detailing the line of Schwalbe, scleral spur, and angle anatomy was obtained for each eye by a single examiner. Trabecular meshwork height was defined as the distance from the scleral spur to the Schwalbe line.

Results: Mean patient age (P = .85, t test), refractive error (P = .68), sex distribution (P = .26, Fisher exact test) and axial length (P = .39) were similar between the groups. Mean +/- SE trabecular meshwork heights were 0.36 +/- 0.03 mm (range, 0.19-0.53 mm) for JPOAG and 0.58 +/- 0.02 mm (range, 0.40-0.80 mm) for controls (P < .001). Eyes with greater axial length tended to have larger trabecular meshworks in both groups (P = .012, multivariate regression). A trabecular meshwork height-axial length ratio of 0.021 or less was associated with a significantly increased risk for JPOAG being present (odds ratio, 57; 95% confidence interval, 6.0-541).

Conclusions: The trabecular meshwork is smaller in eyes with JPOAG compared with that in normal eyes. This finding suggests a structural abnormality that may underlie the reduced outflow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anterior Eye Segment / diagnostic imaging
  • Child
  • Female
  • Glaucoma, Open-Angle / complications
  • Glaucoma, Open-Angle / diagnostic imaging
  • Glaucoma, Open-Angle / pathology*
  • Humans
  • Male
  • Microscopy
  • Middle Aged
  • Trabecular Meshwork / diagnostic imaging
  • Trabecular Meshwork / pathology*
  • Ultrasonography