Molecular cloning and tissue distribution of rat peptide transporter PEPT2

Biochim Biophys Acta. 1996 Apr 26;1280(2):173-7. doi: 10.1016/0005-2736(96)00024-7.


A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / genetics*
  • Cloning, Molecular
  • DNA, Complementary
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats
  • Sequence Homology, Amino Acid
  • Symporters*
  • Xenopus / genetics


  • Carrier Proteins
  • DNA, Complementary
  • RNA, Messenger
  • Symporters
  • hydrogen-coupled oligopeptide transporter PepT2

Associated data

  • GENBANK/D63149