Lack of constitutive activation of Janus kinases and signal transduction and activation of transcription factors in Philadelphia chromosome-positive acute lymphoblastic leukemia

Blood. 1996 Jun 1;87(11):4911-2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA-Binding Proteins / metabolism*
  • Enzyme Activation
  • Fusion Proteins, bcr-abl / metabolism
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Janus Kinase 1
  • Janus Kinase 2
  • Janus Kinase 3
  • Milk Proteins*
  • Neoplasm Proteins / metabolism*
  • Phosphorylation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Protein Processing, Post-Translational*
  • Protein-Tyrosine Kinases / metabolism*
  • Proteins / metabolism*
  • Proto-Oncogene Proteins*
  • STAT5 Transcription Factor
  • Signal Transduction*
  • TYK2 Kinase
  • Trans-Activators / metabolism*
  • Tumor Cells, Cultured

Substances

  • DNA-Binding Proteins
  • Milk Proteins
  • Neoplasm Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • STAT5 Transcription Factor
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • Fusion Proteins, bcr-abl
  • JAK1 protein, human
  • JAK2 protein, human
  • JAK3 protein, human
  • Janus Kinase 1
  • Janus Kinase 2
  • Janus Kinase 3
  • TYK2 Kinase
  • TYK2 protein, human