Early diet of preterm infants and bone mineralization at age five years

Acta Paediatr. 1996 Feb;85(2):230-6. doi: 10.1111/j.1651-2227.1996.tb13999.x.


Bone disease with significantly reduced bone mineralization is common in preterm infants, and associated with later linear growth stunting at 18 months of age. Dietary insufficiency of calcium and phosphorus is thought to be the principal aetiological factor. We studied 54 children at mean age 5 years who were born preterm and had participated in a prospective multicentre study of effects of early diet on later growth and development. Diets compared were banked donor breast milk and preterm formula fed as a supplement to mother's own milk. Increasing human milk intake was strongly positively associated with later bone mineral content. Children fed predominantly human milk had greater bone mineral content than children of similar size born at term. These data suggest that the early nutritional environment of the preterm infant could play an important role in determining later skeletal growth and mineralization.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Bone Density*
  • Calcification, Physiologic*
  • Child, Preschool
  • Diet*
  • Eating
  • Female
  • Food, Fortified
  • Humans
  • Infant Nutritional Physiological Phenomena*
  • Infant, Newborn
  • Infant, Premature*
  • Male
  • Milk, Human
  • Sex Factors