Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice

Nat Genet. 1996 Jun;13(2):147-53. doi: 10.1038/ng0696-147.


Mice from various inbred strains consume alcoholic beverages at highly reproducible and strain-specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J animals exhibit sustained oral ingestion of high levels of alcohol in the presence of competing water and food. We now report a genetic investigation of this phenotype as one potential model for alcoholism. An intercross-backcross breeding protocol was used to identify two recessive alcohol preference quantitative trait loci (QTLs) that are both sex-restricted in expression. A comparison of our results with those of an earlier morphine preference study argues against the hypothesis of a single unified phenotype defined by a preference for all euphoria-producing drugs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Drinking / genetics*
  • Alcoholism / genetics
  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Disease Models, Animal
  • Female
  • Genetic Markers
  • Genetics, Population
  • Male
  • Mice
  • Mice, Inbred C57BL / genetics*
  • Mice, Inbred DBA
  • Phenotype
  • Regression Analysis
  • Reproducibility of Results


  • Genetic Markers