Characterization of DRP2, a novel human dystrophin homologue

Nat Genet. 1996 Jun;13(2):223-6. doi: 10.1038/ng0696-223.


The currently recognised dystrophin protein family comprises the archetype, dystrophin, its close relative, utrophin or dystrophin-related protein (DRP), and a distantly related protein known as the 87K tyrosine kinase substrate. During the course of a phylogenetic study of sequences encoding the characteristic C-terminal domains of dystrophin-related proteins, we identified an unexpected novel class of vertebrate dystrophin-related sequences. We term this class dystrophin-related protein 2 (DRP2), and suggest that utrophin/DRP be renamed DRP1 to simplify future nomenclature. DRP2 is a relatively small protein, encoded in man by a 45 kb gene localized to Xq22. It is expressed principally in the brain and spinal cord, and is similar in overall structure to the Dp116 dystrophin isoform. The discovery of a novel relative of dystrophin substantially broadens the scope for study of this interesting group of proteins and their associated glycoprotein complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cytoskeletal Proteins / chemistry*
  • Cytoskeletal Proteins / classification
  • Cytoskeletal Proteins / genetics*
  • Dogfish / genetics
  • Dystrophin / biosynthesis
  • Dystrophin / chemistry*
  • Dystrophin / genetics*
  • Fishes / genetics
  • Humans
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • Muscle Proteins*
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid*
  • Tissue Distribution
  • Utrophin
  • X Chromosome


  • Cytoskeletal Proteins
  • Dystrophin
  • Membrane Proteins
  • Muscle Proteins
  • Utrn protein, mouse
  • Utrophin
  • dystrophin-related protein 2

Associated data

  • GENBANK/U43517
  • GENBANK/U43518
  • GENBANK/U43519
  • GENBANK/U43520