Changes in Susceptibility of Salmonella Enteritidis, Salmonella Typhimurium, and Salmonella Virchow to Six Antimicrobial Agents in a Spanish Hospital, 1980-1994

Eur J Clin Microbiol Infect Dis. 1996 Jan;15(1):85-8. doi: 10.1007/BF01586193.

Abstract

To determine changes in the susceptibility patterns of Salmonella enteritidis, Salmonella typhimurium, and Salmonella virchow over time, resistance to ampicillin, chloramphenicol, tetracycline, gentamicin, trimethoprim/sulfamethoxazole, and nalidixic acid was studied by the disk diffusion method in 1,024, 191, and 61 clinical isolates of these organisms, respectively. All isolates were recovered from 1980 to 1994 at a hospital in Madrid, Spain. Salmonella enteritidis isolates were less resistant (10.9%) than Salmonella typhimurium (43.5%) and Salmonella virchow (36.1%; p < 0.001). The incidence of resistance of Salmonella enteritidis to ampicillin increased from 2.7% during the period 1980-1982 to 15.6% during 1992-1994 (p < 0.001). The resistance of Salmonella typhimurium to ampicillin, chloramphenicol, and tetracycline increased from 15.2%, 7.6%, and 21.2% respectively in 1980-1982 to 73.3%, 46.7%, and 73.3% in 1992-1994 (p < 0.001). These marked increases in antimicrobial resistance suggest the need for public health interventions, several of which are discussed.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Salmonella / drug effects*
  • Salmonella enteritidis / drug effects*
  • Salmonella typhimurium / drug effects*
  • Time Factors

Substances

  • Anti-Bacterial Agents