Interferons induce accumulation of diadenosine triphosphate (Ap3A) in human cultured cells

FEBS Lett. 1996 Feb 26;381(1-2):32-4. doi: 10.1016/0014-5793(96)00073-7.


After incubation of human monocytes J96 and human myeloid leukemia HL60 cells with interferons (IFN) alpha or gamma, the Ap3A concentration considerably increases in parallel with accumulation of tryptophanyl-tRNA synthetase (TrpRS, EC The Ap3A formation in response to IFNs is catalysed by an excessive amount of TrpRS. Although the Ap3A function still remains unknown, its accumulation may imply the Ap3A involvement in the IFN-signalling pathway.

MeSH terms

  • Cell Line
  • Chromatography, Thin Layer
  • Dinucleoside Phosphates / biosynthesis*
  • Dinucleoside Phosphates / isolation & purification
  • HL-60 Cells
  • Humans
  • Interferon-alpha / pharmacology*
  • Interferon-gamma / pharmacology*
  • Kinetics
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Phosphates / metabolism
  • Signal Transduction


  • Dinucleoside Phosphates
  • Interferon-alpha
  • Phosphates
  • diadenosine triphosphate
  • Interferon-gamma