EI-1507-1 and -2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1507

J Antibiot (Tokyo). 1996 Apr;49(4):333-9. doi: 10.7164/antibiotics.49.333.

Abstract

EI-1507-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1507. EI-1507-1 and EI-1507-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.23 and 0.42 microM, respectively. EI-1507-1 and EI-1507-2 also inhibited mature interleukin-1 beta secretion from THP-1 cells with IC50 values of 1.1 and 1.4 microM, respectively.

MeSH terms

  • Amino Acid Sequence
  • Anthraquinones / chemistry*
  • Anthraquinones / classification
  • Anthraquinones / pharmacology
  • Benz(a)Anthracenes / chemistry*
  • Benz(a)Anthracenes / classification
  • Benz(a)Anthracenes / pharmacology
  • Caspase 1
  • Cell Survival / drug effects
  • Cysteine Endopeptidases / biosynthesis*
  • Cysteine Proteinase Inhibitors / chemistry*
  • Cysteine Proteinase Inhibitors / classification
  • Cysteine Proteinase Inhibitors / pharmacology
  • Dose-Response Relationship, Drug
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Sequence Data
  • Molecular Structure
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Streptomyces / growth & development
  • Streptomyces / metabolism*
  • Streptomyces / physiology

Substances

  • Anthraquinones
  • Benz(a)Anthracenes
  • Cysteine Proteinase Inhibitors
  • EI 1507-1
  • EI 1507-2
  • Cysteine Endopeptidases
  • Caspase 1