3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor

J Med Chem. 1996 May 10;39(10):1941-2. doi: 10.1021/jm9600712.

Authors

J J Kulagowski¹, H B Broughton, N R Curtis, I M Mawer, M P Ridgill, R Baker, F Emms, S B Freedman, R Marwood, S Patel, S Patel, C I Ragan, P D Leeson

Affiliation

¹ Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.

PMID: 8642550
DOI: 10.1021/jm9600712

No abstract available

MeSH terms

Animals
Cell Line
Dopamine Antagonists / chemistry
Dopamine Antagonists / pharmacology*
Dopamine D2 Receptor Antagonists*
Humans
Pyridines / chemistry
Pyridines / pharmacology*
Pyrroles / chemistry
Pyrroles / pharmacology*
Receptors, Dopamine D4

Substances

3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine
DRD4 protein, human
Dopamine Antagonists
Dopamine D2 Receptor Antagonists
Pyridines
Pyrroles
Receptors, Dopamine D4