Changes in metabolism of collagen in genitourinary prolapse

Abstract

Background: Genitourinary prolapse is a common problem, the pathophysiology of which is unknown.

Methods: We analysed vaginal-epithelial tissue from premenopausal women with genitourinary prolapse and compared them with controls.

Findings: We found that genitourinary prolapse is associated with a reduction in total collagen content and a decrease in collagen solubility. Both intermediate intermolecular cross-links and advanced glycation cross-links were increased in prolapse tissue. Collagen turnover, as indicated by matrix metalloproteinase activity, was up to four times higher in prolapse tissue. Collagen-type ratios, mature cross-link pyridinoline and total elastin content were similar in both prolapse and control tissues. Increased collagenolytic activity causes loss of collagen from prolapse tissue.

Interpretation: Based on these findings, we have identified a probable mechanism for genitourinary prolapse. Development of agents to inhibit collagenolytic activity may help in the treatment of this condition.