Diabetes mellitus, a predictor of morbidity and mortality in the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry

Am J Cardiol. 1996 May 1;77(11):1017-20. doi: 10.1016/s0002-9149(97)89163-1.


Diabetes is an independent predictor of morbidity and mortality in patients with symptomatic heart failure, patients with asymptomatic left ventricular dysfunction (defined as an ejection fraction of 35% or less), and in a broader registry population with less stringent entry criteria. Although the SOLVD Trials made a major clinical contribution by proving the value of enalapril, diabetes remains a significant predictor of outcome even after adjusting for treatment with enalapril.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Diabetes Complications*
  • Diabetes Mellitus / mortality
  • Enalapril / therapeutic use
  • Female
  • Heart Failure / complications*
  • Heart Failure / drug therapy
  • Humans
  • Male
  • Multicenter Studies as Topic
  • Odds Ratio
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Registries
  • Regression Analysis
  • Risk Factors
  • Ventricular Dysfunction, Left / complications*
  • Ventricular Dysfunction, Left / drug therapy
  • Ventricular Dysfunction, Left / mortality


  • Angiotensin-Converting Enzyme Inhibitors
  • Enalapril