Nosocomial Staphylococcus Aureus Bacteremia Among Nasal Carriers of Methicillin-Resistant and Methicillin-Susceptible Strains

Am J Med. 1996 May;100(5):509-16. doi: 10.1016/s0002-9343(96)00014-9.

Abstract

Objectives: To determine the relevance of nasal carriage of Staphylococcus aureus, either methicillin-sensitive (MSSA) or methicillin-resistant (MRSA), as a risk factor for the development of nosocomial S aureus bacteremia during an MRSA outbreak.

Patients and methods: In this prospective cohort study, 488 patients admitted to an intensive care unit (ICU) during a 1-year period were screened with nasal swabs within 48 hours of admission and weekly thereafter in order to identify nasal S aureus carriage. Nasal staphylococcal carriers were observed until development of S aureus bacteremia, ICU discharge, or death.

Results: One hundred forty-seven (30.1%) of 488 patients were nasal S aureus carriers; 84 patients (17.2%) harbored methicillin-sensitive S aureus; and 63 patients (12.9%) methicillin-resistant S aureus. Nosocomial S aureus bacteremia was diagnosed in 38 (7.7%) of 488 patients. Rates of bacteremia were 24 (38%) of the MRSA carriers, eight (9.5%) of the MSSA carriers, and six (1.7%) of noncarriers. After adjusting for other predictors of bacteremia by means of a Cox proportional hazard regression model, the relative risk for S aureus bacteremia was 3.9 (95% confidence interval, 1.6-9.8; P = 0.002) for MRSA carriers compared with MSSA carriers.

Conclusions: Among ICU patients, nasal carriers of S aureus are at higher risk for S aureus bacteremia than are noncarriers; in the setting of an MRSA outbreak, colonization by methicillin-resistant strains represents a greater risk than does colonization by MSSA and strongly predicts the occurrence of MRSA bacteremia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bacteremia / etiology*
  • Carrier State*
  • Cohort Studies
  • Confidence Intervals
  • Cross Infection / etiology*
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Methicillin / pharmacology*
  • Methicillin Resistance*
  • Middle Aged
  • Nose / microbiology
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Staphylococcal Infections / etiology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification*

Substances

  • Methicillin