Post-prandial thermogenesis with ephedrine, caffeine and aspirin in lean, pre-disposed obese and obese women

Int J Obes Relat Metab Disord. 1996 Feb;20(2):91-7.


Objective: To determine whether or not aspirin further potentiates the greater post-prandial thermogenesis induced by ephedrine with caffeine.

Design: Determination of the acute metabolic rate response to the following treatments: 1050 kJ liquid meal (M); meal plus ephedrine (30 mg) and caffeine (100 mg) (MEC) or meal plus ephedrine, caffeine and aspirin (300 mg) (MECA).

Subjects: Lean, pre-disposed obese and obese women (n = 10 each group).

Measurements: Pre- and post-treatment metabolic rate determinations via indirect calorimetry. Post-treatment measurements made at 20 min intervals for a total of 160 min.

Results: In all groups, metabolic rate increased significantly more following the MEC or MECA, compared to the meal only (p < 0.05). The obese group had a significantly greater absolute increase in metabolic rate following the MECA and MEC compared to both the lean and pre-disposed obese groups (p < 0.05). Metabolic rate remained elevated at the end of the 160 min following all treatments.

Conclusion: Aspirin does not further potentiate the acute thermic effect of ephedrine and caffeine with a meal. However, the full thermogenic response was not measured and longer duration studies are necessary to confirm these results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspirin / administration & dosage
  • Aspirin / pharmacology*
  • Basal Metabolism
  • Body Constitution
  • Body Mass Index
  • Body Temperature Regulation / drug effects*
  • Caffeine / administration & dosage
  • Caffeine / pharmacology*
  • Calorimetry, Indirect
  • Ephedrine / administration & dosage
  • Ephedrine / pharmacology*
  • Female
  • Food*
  • Humans
  • Kinetics
  • Obesity / metabolism*


  • Caffeine
  • Ephedrine
  • Aspirin