The aim of this systematic review was to evaluate the effectiveness of ginkgo biloba in the treatment of intermittent claudication. A Medline-search identified ten controlled trials on the subject. These were heterogeneous in all respects and, with only few exceptions, of poor methodological quality. All the studies implied that ginkgo biloba is an effective therapy for intermittent claudication. This hypothesis should be confirmed in further trials employing meticulous methodology. Furthermore it would also be important to determine whether oral ginkgo biloba can be usefully combined with walking exercise.