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, 275 (24), 1893-6

Serum Folate and Risk of Fatal Coronary Heart Disease


Serum Folate and Risk of Fatal Coronary Heart Disease

H I Morrison et al. JAMA.


Objective: To assess the relationship between serum folate level and the risk of fatal coronary heart disease (CHD) among men and women.

Design: Retrospective cohort study with serum folate levels measured from September 1970 to December 1972, with follow-up through 1985.

Setting: Participants in the Nutrition Canada Survey.

Participants: A total of 5056 Canadian men and women aged 35 to 79 years with no history of self-reported CHD.

Main outcome measure: Fifteen-year CHD mortality.

Results: A total of 165 CHD deaths were observed. We found a statistically significant association between serum folate level and risk of fatal CHD, with rate ratios for individuals in the lowest serum folate level category (<6.8 nmol/L [3 ng/mL]) compared with the highest category (>13.6 nmol/L [6 ng/mL]) of 1.69 (95% confidence interval, 1.10-2.61).

Conclusions: These data indicate that low serum folate levels are associated with an increased risk of fatal CHD.

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