Identification of a Major Co-Receptor for Primary Isolates of HIV-1

Nature. 1996 Jun 20;381(6584):661-6. doi: 10.1038/381661a0.

Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • CD4 Antigens / metabolism*
  • Cell Line
  • Chemokines / metabolism
  • Chemokines / physiology
  • DNA
  • Gene Products, env / metabolism
  • HIV-1 / physiology*
  • HeLa Cells
  • Humans
  • Macrophages / immunology
  • Macrophages / virology*
  • Membrane Fusion
  • Membrane Proteins / metabolism
  • Mice
  • Molecular Sequence Data
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, Cytokine / genetics
  • Receptors, Cytokine / metabolism*
  • Receptors, HIV / genetics
  • Receptors, HIV / metabolism*
  • Recombinant Proteins / metabolism
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology
  • Virus Replication

Substances

  • CD4 Antigens
  • Chemokines
  • Gene Products, env
  • Membrane Proteins
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, Cytokine
  • Receptors, HIV
  • Recombinant Proteins
  • DNA