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, 381 (6584), 667-73

HIV-1 Entry Into CD4+ Cells Is Mediated by the Chemokine Receptor CC-CKR-5

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HIV-1 Entry Into CD4+ Cells Is Mediated by the Chemokine Receptor CC-CKR-5

T Dragic et al. Nature.

Abstract

The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

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