Review
doi: 10.1098/rstb.1996.0008.
The regulation of AP-1 activity by mitogen-activated protein kinases
Affiliations
- PMID: 8650258
- DOI: 10.1098/rstb.1996.0008
Item in Clipboard
Review
The regulation of AP-1 activity by mitogen-activated protein kinases
Philos Trans R Soc Lond B Biol Sci.
.
Abstract
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.
Similar articles
-
Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides.J Immunol. 1999 Oct 1;163(7):3621-8. J Immunol. 1999. PMID: 10490955
-
Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins.J Cell Biochem. 1998 Jun 15;69(4):392-413. J Cell Biochem. 1998. PMID: 9620167
-
Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.J Clin Invest. 1998 Mar 15;101(6):1432-40. doi: 10.1172/JCI2153. J Clin Invest. 1998. PMID: 9502786 Free PMC article.
-
AP-1 function and regulation.Curr Opin Cell Biol. 1997 Apr;9(2):240-6. doi: 10.1016/s0955-0674(97)80068-3. Curr Opin Cell Biol. 1997. PMID: 9069263 Review.
-
The regulation of AP-1 activity by mitogen-activated protein kinases.J Biol Chem. 1995 Jul 14;270(28):16483-6. doi: 10.1074/jbc.270.28.16483. J Biol Chem. 1995. PMID: 7622446 Review. No abstract available.
Cited by
-
Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.PLoS One. 2012;7(5):e35779. doi: 10.1371/journal.pone.0035779. Epub 2012 May 11. PLoS One. 2012. PMID: 22606234 Free PMC article.
-
The role of MEKK1 in hypertrophic cardiomyopathy.Int Heart J. 2010 Jul;51(4):277-84. doi: 10.1536/ihj.51.277. Int Heart J. 2010. PMID: 20716846 Free PMC article.
-
Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses.Cells. 2020 May 14;9(5):1216. doi: 10.3390/cells9051216. Cells. 2020. PMID: 32422978 Free PMC article.
-
Complement Receptor-Mediated Phagocytosis Induces Proinflammatory Cytokine Production in Murine Macrophages.Front Immunol. 2020 Jan 14;10:3049. doi: 10.3389/fimmu.2019.03049. eCollection 2019. Front Immunol. 2020. PMID: 31993058 Free PMC article.
-
Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for….Biochem Soc Trans. 2020 Oct 30;48(5):1859-1875. doi: 10.1042/BST20190338. Biochem Soc Trans. 2020. PMID: 32915196 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
