The regulation of AP-1 activity by mitogen-activated protein kinases

Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):127-34. doi: 10.1098/rstb.1996.0008.


AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Calcium-Calmodulin-Dependent Protein Kinases / physiology*
  • Signal Transduction / physiology*
  • Transcription Factor AP-1 / physiology*


  • Transcription Factor AP-1
  • Calcium-Calmodulin-Dependent Protein Kinases