Testosterone decreases lipoprotein(a) in men

Am J Cardiol. 1996 Jun 1;77(14):1244-7. doi: 10.1016/s0002-9149(96)00174-9.


We administered testosterone, with or without the aromatase inhibitor testolactone, to determine the effects of testosterone and its aromatization to estradiol on Lp(a) levels in normal men. Average Lp (a) values decreased by 37% during testosterone alone and by 28% when testosterone and testolactone were combined, suggesting that testosterone reduces Lp(a) in men primarily by an androgenic effect and not by its conversion to estradiol.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Cross-Over Studies
  • Estradiol / metabolism
  • Humans
  • Lipoprotein(a) / blood
  • Lipoprotein(a) / drug effects*
  • Male
  • Testosterone / metabolism
  • Testosterone / pharmacology*


  • Lipoprotein(a)
  • Testosterone
  • Estradiol