Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

Am J Hum Genet. 1996 Jun;58(6):1279-85.


In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.

MeSH terms

  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 21*
  • Disease Susceptibility
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Nuclear Family
  • Pedigree
  • Polymerase Chain Reaction
  • Repetitive Sequences, Nucleic Acid
  • Risk Assessment


  • Genetic Markers