HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height

Behav Neurosci. 1996 Feb;110(1):117-25. doi: 10.1037//0735-7044.110.1.117.


Rats with unilateral dopamine (DA) depletion (hemiParkinson analogue rats) are impaired in using the contralateral (bad) limbs for skilled movements and for postural adjustments and compensate by using their good limbs in novel ways. The present study consisted of a reaching task in which compensatory adjustments using the good limbs would not be affective, thus forcing the rats to use their bad limbs. The DA-depleted rats failed to use their bad hindlimb to extend their reach at high reaching heights and failed to lower their body with their bad forelimb to reach at low reaching heights. It is suggested that extensive DA depletion may result in the loss of the ability to apply forces with the affected limbs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Appetitive Behavior / drug effects
  • Appetitive Behavior / physiology*
  • Brain Mapping
  • Corpus Striatum / drug effects
  • Corpus Striatum / physiopathology
  • Dominance, Cerebral / drug effects
  • Dominance, Cerebral / physiology
  • Dopamine / physiology
  • Female
  • Forelimb / innervation*
  • Functional Laterality / drug effects
  • Functional Laterality / physiology*
  • Hindlimb / innervation*
  • Orientation / drug effects
  • Orientation / physiology*
  • Oxidopamine / pharmacology
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / physiopathology*
  • Postural Balance / drug effects
  • Postural Balance / physiology*
  • Posture / physiology*
  • Psychomotor Performance / drug effects
  • Psychomotor Performance / physiology*
  • Rats
  • Substantia Nigra / drug effects
  • Substantia Nigra / physiopathology


  • Oxidopamine
  • Dopamine