Abstract
Tumour necrosis Factor (TNF), Interleukin 1alpha and beta (IL-alpha and IL-beta), Interleukin 7 (IL-7) and Stem Cell Factor (SCF) are cytokines synthesized by immune system cells under stimulation of various agents. Apoptosis, or programmed cell death, is a process that appears in response to specific stimuli, apparently following an intrinsic program. In this work we examined, in RA-1 human lymphoblastoid B cell line, the effect induced by different cytokines in cell proliferation and in programmed cell death. After 48 hours of treatment is present an antiproliferative affects, detected by 3H-thymidine incorporation and morphological changes related to apoptotic process.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects*
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Burkitt Lymphoma / drug therapy
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / pathology*
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Cell Differentiation / drug effects
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Chromatin / drug effects
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Cytokines / pharmacology*
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Electrophoresis
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Flow Cytometry
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Humans
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Interleukin-1 / pharmacology
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Interleukin-7 / pharmacology
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Recombinant Proteins / pharmacology
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Stem Cell Factor / pharmacology
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Thymidine / metabolism
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Thymidine / pharmacokinetics
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha / pharmacology
Substances
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Chromatin
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Cytokines
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Interleukin-1
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Interleukin-7
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Recombinant Proteins
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Stem Cell Factor
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Tumor Necrosis Factor-alpha
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Thymidine