Evaluation of intraocular pressure with Healon and Healon GV in sutureless cataract surgery with foldable lens implantation

J Cataract Refract Surg. 1996 Mar;22(2):227-37. doi: 10.1016/s0886-3350(96)80224-0.


Purpose: To evaluate transient increases in intraocular pressure (IOP) after use of high-viscosity viscoelastic agents in cataract surgery.

Setting: Military Hospital, Ulm, Germany.

Methods: In a prospective, randomized study, we evaluated IOP following cataract surgery using two different viscoelastic substances (Healon, Healon GV). The viscosity of Healon GV is 10 times higher than that of Healon because of higher concentration and molecular weight. Patients having identical phacoemulsification procedures (sutureless clear corneal tunnel incision with foldable silicone lens implantation) (N = 60) and identical viscoelastic removal were assigned to groups of 15 based on viscoelastic used and removal time (20 or 40 seconds). Intraocular pressure was measured preoperatively and at 6, 24, 36, and 48 hours and 1 month postoperatively.

Results: The highest mean IOP elevations in both viscoelastic groups were obtained at 24 hours postoperatively (2.9 mm Hg +/- 4.3 [SD] with Healon and 3.3 +/- 6.3 mm Hg with Healon GV). There were no statistically significant differences between the two viscoelastics and the two removal times during the entire follow-up period (unpaired t-test), but standard deviations were higher in the Healon GV groups at 6 and 24 hours. Two patients in the Healon groups and three in the Healon GV groups required medical treatment for IOP within the first 24 postoperative hours; however, all five patients had an IOP lower than 22 mm Hg on the second postoperative day.

Conclusions: Based on postoperative IOP, both viscoelastics can be equally well removed from the anterior chamber. Incidence of high IOP using high-viscosity hyaluronic acid is minimized by the described removal technique.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Drainage / methods
  • Humans
  • Hyaluronic Acid / adverse effects*
  • Intraocular Pressure*
  • Lenses, Intraocular*
  • Middle Aged
  • Ocular Hypertension / chemically induced*
  • Phacoemulsification*
  • Postoperative Complications
  • Prospective Studies
  • Suture Techniques*
  • Viscosity


  • Hyaluronic Acid