Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum

Planta Med. 1996 Apr;62(2):175-6. doi: 10.1055/s-2006-957846.

Abstract

Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 micrograms/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Arachidonic Acid / pharmacology
  • Collagen / pharmacology
  • Plants, Medicinal*
  • Platelet Activating Factor / pharmacology
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Platelet Aggregation Inhibitors / pharmacology
  • Quinazolines / isolation & purification*
  • Quinazolines / pharmacology
  • Rabbits
  • Taiwan
  • Thrombin / pharmacology

Substances

  • Alkaloids
  • Platelet Activating Factor
  • Platelet Aggregation Inhibitors
  • Quinazolines
  • Arachidonic Acid
  • Collagen
  • Thrombin