Abstract
Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 micrograms/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Arachidonic Acid / pharmacology
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Collagen / pharmacology
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Plants, Medicinal*
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Platelet Activating Factor / pharmacology
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Quinazolines / isolation & purification*
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Quinazolines / pharmacology
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Rabbits
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Taiwan
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Thrombin / pharmacology
Substances
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Alkaloids
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Platelet Activating Factor
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Platelet Aggregation Inhibitors
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Quinazolines
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Arachidonic Acid
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Collagen
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Thrombin