Membranous glomerulonephritis associated with inflammatory demyelinating peripheral neuropathies

Am J Kidney Dis. 1996 Feb;27(2):279-83. doi: 10.1016/s0272-6386(96)90554-5.


A 55-year-old man with chronic inflammatory demyelinating polyradiculoneuropathy developed the nephrotic syndrome. Renal biopsy showed stage I membranous glomerulonephritis. Review of the literature revealed the association of these two rare syndromes, considered to be due to immunologic dysfunction, in two other cases, as well as several cases of the acute form of demyelinating peripheral polyradiculoneuropathy. The nephrotic syndrome appears to be persistent in the chronic form of the peripheral neuropathy but reversible in its acute form following immunosuppressive therapy. The possibility of a common immunopathogenesis in the association of membranous glomerulonephritis and inflammatory demyelinating peripheral neuropathies deserves further scrutiny.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Chronic Disease
  • Demyelinating Diseases / complications*
  • Demyelinating Diseases / epidemiology
  • Demyelinating Diseases / immunology
  • Glomerulonephritis, Membranous / complications*
  • Glomerulonephritis, Membranous / epidemiology
  • Glomerulonephritis, Membranous / immunology
  • Humans
  • Kidney Glomerulus / immunology
  • Kidney Glomerulus / pathology
  • Male
  • Middle Aged
  • Nephrotic Syndrome / etiology
  • Polyradiculoneuropathy / complications*
  • Polyradiculoneuropathy / epidemiology
  • Polyradiculoneuropathy / immunology