Use of the ganciclovir implant in the treatment of recurrent cytomegalovirus retinitis

Arch Ophthalmol. 1996 Jul;114(7):815-20. doi: 10.1001/archopht.1996.01100140029003.


Objective: To evaluate the efficacy of the ganciclovir implant in the treatment of recurrent cytomegalovirus (CMV) retinitis.

Methods: Patients with acquired immunodeficiency syndrome and recurrent CMV retinitis were evaluated for entry into the study. A ganciclovir implant was inserted in 91 eyes of 70 patients between October 1992 and October 1995. The efficacy of the implant and visual results were retrospectively reviewed.

Results: Fifty-three (76%) of 70 eyes had inactive CMV retinitis 1 month postoperatively (positive initial response). Twenty-one eyes of 19 patients had less than 1 month of follow-up. Nineteen (36%) of 53 eyes developed recurrent CMV retinitis. The median time to recurrence for those patients with a positive initial response was 7 months. Forty-eight (84%) of 57 patients with follow-up longer than 1 month after implant insertion in the first eye received systemic anti-CMV medication during the study. The cumulative risk for developing a retinal detachment was 23% at 6 months following implant insertion. Other complications included vitreous hemorrhage, hyphema, and suprachoroidal implantation of the device.

Conclusion: The ganciclovir implant is effective as an adjunct to continued systemic therapy in those patients with recurrent CMV retinitis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / drug therapy*
  • AIDS-Related Opportunistic Infections / pathology
  • Adolescent
  • Adult
  • Antiviral Agents / therapeutic use*
  • Child
  • Cytomegalovirus Retinitis / complications
  • Cytomegalovirus Retinitis / drug therapy*
  • Cytomegalovirus Retinitis / pathology
  • Drug Implants
  • Female
  • Follow-Up Studies
  • Fundus Oculi
  • Ganciclovir / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Treatment Outcome
  • Visual Acuity


  • Antiviral Agents
  • Drug Implants
  • Ganciclovir