The human PECAM1 gene maps to 17q23

Genomics. 1996 Jun 1;34(2):229-32. doi: 10.1006/geno.1996.0272.


We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBD nomenclature) using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ibalpha) has been provisionally mapped to the region 17p12-pter, the ITGA2B (GPIIb) and the ITGB3 (GPIIIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, in the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, CD / genetics
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17*
  • Cricetinae
  • DNA Primers
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Integrin beta3
  • Karyotyping
  • Molecular Sequence Data
  • Platelet Endothelial Cell Adhesion Molecule-1 / biosynthesis
  • Platelet Endothelial Cell Adhesion Molecule-1 / genetics*
  • Platelet Glycoprotein GPIIb-IIIa Complex / genetics
  • Platelet Membrane Glycoproteins / genetics
  • Polymerase Chain Reaction / methods


  • Antigens, CD
  • DNA Primers
  • Integrin beta3
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Membrane Glycoproteins