Abstract
The transforming growth factor-beta (TGF-beta) superfamily regulates a multitude of cellular and developmental events. TGF-beta family ligands signal through transmembrane serine/threonine kinase receptors whose downstream effectors are largely unknown. Using genetic data from the fruit fly, we have identified a downstream effector of TGF-beta-induced signaling. TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta. Localization of bsp-1 to chromosome 4q28 suggests a role in carcinogenesis. These data suggest that BSP-1 is the prototype of a new class of signaling molecules.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Chromosome Mapping
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Chromosomes, Human, Pair 4
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Cloning, Molecular
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DNA-Binding Proteins / genetics
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Humans
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Molecular Sequence Data
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Phosphorylation
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Proteins / genetics*
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Proteins / metabolism*
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Repressor Proteins*
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Sequence Homology, Amino Acid
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Serine / metabolism
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Signal Transduction*
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Smad Proteins
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Trans-Activators*
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Transforming Growth Factor beta / metabolism*
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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MXD1 protein, human
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Proteins
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Repressor Proteins
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Smad Proteins
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Trans-Activators
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Transforming Growth Factor beta
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Serine