New perspectives on eye evolution

Curr Opin Genet Dev. 1995 Oct;5(5):602-9. doi: 10.1016/0959-437x(95)80029-8.

Abstract

The highly complex eyes of vertebrates, insects and molluscs have long been considered to be of independent evolutionary origin. Recently, however, Pax-6, a highly conserved transcription factor, has been identified as a key regulator of eye development in both mammals and flies. Homologues of Pax-6 have also been identified in species from other phyla, including molluscs. The wide variety of eyes in the animal kingdom may, therefore, have evolved from a single ancestral photosensitive origin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Brain / physiology
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Drosophila
  • Eye / anatomy & histology*
  • Eye Proteins
  • Homeodomain Proteins*
  • Humans
  • Insecta
  • Mammals
  • Models, Biological
  • Mollusca
  • Ocular Physiological Phenomena*
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Photoreceptor Cells / anatomy & histology
  • Photoreceptor Cells / physiology
  • Photoreceptor Cells, Invertebrate / anatomy & histology
  • Photoreceptor Cells, Invertebrate / physiology
  • Repressor Proteins
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics
  • Vertebrates
  • Visual Pathways / anatomy & histology
  • Visual Pathways / physiology

Substances

  • DNA-Binding Proteins
  • Eye Proteins
  • Homeodomain Proteins
  • PAX6 Transcription Factor
  • PAX6 protein, human
  • Paired Box Transcription Factors
  • Repressor Proteins
  • Transcription Factors