Molecular control of circadian rhythms

Curr Opin Genet Dev. 1995 Oct;5(5):662-8. doi: 10.1016/0959-437x(95)80037-9.


Circadian rhythms are virtually ubiquitous in eukaryotes and have been shown to exist even in some prokaryotes. The generally accepted view is that these rhythms are generated by an endogenous clock. Recent progress, especially in the Drosophila, Neurospora and mouse systems, has revealed new clock components and mechanisms. These include the mouse clock gene, the Drosophila timeless gene, and the role of light in Neurospora.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks
  • Biological Evolution
  • Circadian Rhythm / genetics*
  • Drosophila / physiology
  • Drosophila Proteins*
  • Gene Expression
  • Genes, Fungal
  • Genes, Insect
  • Mice
  • Mutation
  • Neurospora / physiology
  • Nuclear Proteins / biosynthesis
  • Period Circadian Proteins
  • Proteins / genetics
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis


  • Drosophila Proteins
  • Nuclear Proteins
  • PER protein, Drosophila
  • Period Circadian Proteins
  • Proteins
  • RNA, Messenger
  • tim protein, Drosophila