Leuprolide treatment of sexual aggression in a patient with Dementia and the Klüver-Bucy syndrome

Clin Neuropharmacol. 1995 Oct;18(5):443-7. doi: 10.1097/00002826-199510000-00007.


A patient with dementia and features of the Klüver-Bucy syndrome was treated for verbal, physical, and sexually aggressive behavior disturbances. Propranolol was effective in controlling verbal and physical aggression but not sexually aggressive and inappropriate behaviors. The latter responded completely to treatment with leuprolide. The differential response to these treatments suggests that two basic forms of aggressive behavior in demented men can be identified and treated with relative specificity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aggression / drug effects*
  • Brain Diseases / drug therapy*
  • Dementia / drug therapy*
  • Humans
  • Leuprolide / therapeutic use*
  • Male
  • Sexual Behavior / drug effects*


  • Leuprolide