[Agreement between information supplied by the patient and a family member on medical history, consumption of tobacco, alcohol and coffee and diet in cancer of the exocrine pancreas and extrahepatic biliary tract]

Gac Sanit. 1995 Nov-Dec;9(51):334-42. doi: 10.1016/s0213-9111(95)71258-4.
[Article in Spanish]


Objective: No study on mutations in the K-ras oncogene and cancer of the exocrine pancreas or cancer of the biliary system has analyzed the reliability of clinical and epidemiological information.

Methods: Agreement between patient and surrogate on factors potentially related to both tumours was evaluated within a multicentre prospective study. Interviews were personally administered to both patient and surrogate (N = 110 pairs). Agreement was examined via the simple kappa index (k), the weighted kappa index (kw), the percentage of simple agreement, and the percentages of positive and negative agreement.

Results: Agreement for medical history was excellent (k between 0.89 and 0.76), as it was for tobacco consumption (k = 0.98). Agreement was moderate for coffee consumption (k = 0.68), frequencies of food groups (kw from 0.66 to 0.38), and consumption of alcoholic drinks (k from 0.66 to 0.32). Surrogates indicated a higher consumption of alcohol than patients.

Conclusion: Surrogates can be an alternative source of information when patients cannot be interviewed, but information on alcohol consumption should be treated with caution.

Publication types

  • Comparative Study
  • English Abstract
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking
  • Bile Duct Neoplasms / epidemiology*
  • Bile Ducts, Extrahepatic*
  • Coffee
  • Diet
  • Family*
  • Female
  • Humans
  • Male
  • Medical History Taking*
  • Middle Aged
  • Pancreatic Neoplasms / epidemiology*
  • Patients*
  • Prospective Studies
  • Smoking


  • Coffee