[The effect of an extract of sea buckthorn (Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats]

Khirurgiia (Sofiia). 1995;48(3):30-3.
[Article in Bulgarian]


The effect exerted by Hippophaë rhamnoides L. extract on the healing of experimental wounds in rats is studied histomorphologically in dynamics. The animals are divided up in three groups, as follows: group one--controls, group two--controls treated with indifferent carrier (carbopol gel), and group three--experimental, treated with carbopol gel containing extract of Hippophaë rhamnoides L. The wounds induced are standard, oval to elliptic with diameter about 3 cm. In groups I and II they are subjected to daily daubing over a 10-day period. The study of cytologic smears at 8, 24 and 48 hours, and biopsy performed on the 10th day show that in group three the epithelization is more intensive and occurs earlier, and granulation tissue differentiation (mature collagen fibers, profuse vascularity) is quicker, by comparison with groups one and two. The markedly expressed stimulating effect on the healing process is explained with the rich content of vitamins (A, C, E etc.) and microelements (sulfur, selenium, zinc, copper etc.) in the extract used.

Publication types

  • Comparative Study

MeSH terms

  • Acrylic Resins
  • Animals
  • Biopsy
  • Disease Models, Animal
  • Drug Carriers
  • Gels
  • Male
  • Plant Extracts / pharmacology*
  • Polyvinyls / pharmacology
  • Protease Inhibitors / pharmacology
  • Rats
  • Skin / drug effects*
  • Skin / injuries*
  • Skin / pathology
  • Stimulation, Chemical
  • Time Factors
  • Wound Healing / drug effects*


  • Acrylic Resins
  • Drug Carriers
  • Gels
  • Plant Extracts
  • Polyvinyls
  • Protease Inhibitors
  • carboxypolymethylene