Technetium-99m labelled human immunoglobulin scintigraphy predicts rheumatoid arthritis in patients with arthralgia

Scand J Rheumatol. 1996;25(3):155-8. doi: 10.3109/03009749609080006.


The ability of 99mTc-IgG scintigraphy to predict the development of rheumatoid arthritis (RA) in 47 patients with arthralgia was investigated. 99mTc-IgG scintigraphy and the serum test for rheumatoid factor (RF), measured at the beginning of a year long study, were compared for their ability to predict RA. During the study 8 patients developed RA. The specificity and positive predictive values of RF in predicting RA were 79% and 50% respectively; and for 99mTc-IgG scintigraphy 97% and 88%. The sensitivity and negative predictive values of RF were 100% and of 99mTc-IgG-scintigraphy 88% and 97% respectively. In conclusion, 99mTc-IgG scintigraphy has additional value to RF with respect to the prediction of the development of RA in patients with arthralgia.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Arthralgia / complications
  • Arthralgia / diagnostic imaging*
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / diagnostic imaging*
  • Female
  • Humans
  • Immunoglobulin G*
  • Immunoglobulins*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Radionuclide Imaging
  • Rheumatoid Factor / blood
  • Sensitivity and Specificity
  • Technetium*


  • Immunoglobulin G
  • Immunoglobulins
  • technetium Tc 99m immunoglobulin
  • Technetium
  • Rheumatoid Factor