Lack of expression of c-erbB-2 oncoprotein in human esophageal squamous cell carcinomas

Anticancer Res. Nov-Dec 1995;15(6B):2797-8.

Abstract

Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Breast Neoplasms / chemistry
  • Carcinoma, Squamous Cell / chemistry*
  • Carcinoma, Squamous Cell / pathology
  • Cytoplasm / chemistry
  • Epithelium / chemistry
  • Esophageal Neoplasms / chemistry*
  • Esophageal Neoplasms / pathology
  • Humans
  • Immunoenzyme Techniques
  • Mice
  • Myeloma Proteins / analysis
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / immunology
  • Neoplasm Proteins / physiology
  • Receptor, ErbB-2 / analysis*
  • Receptor, ErbB-2 / immunology
  • Receptor, ErbB-2 / physiology
  • Retrospective Studies

Substances

  • Antibodies, Monoclonal
  • Myeloma Proteins
  • Neoplasm Proteins
  • Receptor, ErbB-2