Steroid contraceptive use and cervical dysplasia: increased risk of progression

E Stern; A B Forsythe; L Youkeles; C F Coffelt

doi:10.1126/science.867043

Steroid contraceptive use and cervical dysplasia: increased risk of progression

Science. 1977 Jun 24;196(4297):1460-2. doi: 10.1126/science.867043.

Authors

E Stern, A B Forsythe, L Youkeles, C F Coffelt

PMID: 867043
DOI: 10.1126/science.867043

Abstract

In a prospective study of women with dysplasia of the cervix, there was an increase in severity of dysplasia and of conversion to cancer in situ in users of the contraceptive pill compared with users of other contraceptive methods. There was a delay in this adverse response. Nonreversal of dysplasia within the first 6 months of pill use is predictive of progression after prolonged exposure.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Contraceptives, Oral / adverse effects*
Female
Humans
Prospective Studies
Uterine Cervical Dysplasia / pathology*
Uterine Cervical Neoplasms / chemically induced*
Uterine Cervical Neoplasms / pathology*

Substances

Contraceptives, Oral