Cell Cycle Regulation by the Retinoblastoma Family of Growth Inhibitory Proteins

Biochim Biophys Acta. 1996 Jun 7;1287(2-3):103-20. doi: 10.1016/0304-419x(96)00002-9.

Abstract

The retinoblastoma family of growth-inhibitory proteins act by binding and inhibiting several proteins with growth-stimulatory activity, the most prominent of which is the cellular transcription factor E2F. In higher organisms, progression through the cell division cycle is accompanied by the cyclical activation of a number of protein kinases, the cyclin-dependent kinases. Phosphorylation of retinoblastoma family proteins by these cyclin-dependent kinases leads to release of the associated growth-stimulatory proteins which in turn mediate progression through the cell division cycle.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins*
  • Cell Cycle / physiology*
  • Cell Cycle Proteins*
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / genetics
  • Cyclins / metabolism*
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Gene Expression Regulation
  • Growth Inhibitors / metabolism*
  • Humans
  • Mitosis
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Retinoblastoma Protein / metabolism*
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors / metabolism

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • Cyclins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Growth Inhibitors
  • Retinoblastoma Protein
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors
  • Cyclin-Dependent Kinases