Regional 133xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment

Biol Psychiatry. 1995 Oct 1;38(7):429-37. doi: 10.1016/0006-3223(94)00305-m.


We previously reported increased regional cerebral cortical uptake and decreased caudate nucleus uptake of 99mTc-HMPAO in patients with obsessive-compulsive disorder(OCD) before treatment compared to matched normal controls. In the present study, we determined whether or not these changes persisted during treatment. Single-photon emission computed tomography was used to measure regional cerebral blood flow (rCBF) by 133Xe inhalation and cerebral uptake of 99mTc-HMPAO in eight adult male OCD patients before and during treatment with chlomipramine, and in eight age-matched normal male controls. With 133Xe, there were no significant differences in rCBF between patients with OCD and their matched controls, and no significant differences in rCBF in the patients before and during treatment. Significantly increased HMPAO uptake in the orbital frontal cortex, posterofrontal cortex, and high dorsal parietal cortex bilaterally occurred in the OCD patients before treatment compared to their matched controls, and there were significant reductions of HMPAO uptake, into the normal range, in all these areas in the patients during treatment. Significantly reduced HMPAO uptake in the caudate nucleus bilaterally occurred in the patients before treatment compared to their matched controls, and these reductions persisted during treatment. This study provides additional support for the involvement of both the orbital frontal cortex and the caudate nuclei in the pathophysiology of OCD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain / blood supply*
  • Caudate Nucleus / drug effects
  • Caudate Nucleus / physiology
  • Cerebral Cortex / blood supply
  • Clomipramine / adverse effects
  • Clomipramine / therapeutic use*
  • Contrast Media
  • Dominance, Cerebral / drug effects
  • Dominance, Cerebral / physiology
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / diagnostic imaging*
  • Obsessive-Compulsive Disorder / drug therapy
  • Obsessive-Compulsive Disorder / psychology
  • Organotechnetium Compounds
  • Oximes
  • Reference Values
  • Regional Blood Flow / drug effects
  • Regional Blood Flow / physiology
  • Serotonin Uptake Inhibitors / adverse effects
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon*
  • Xenon Radioisotopes


  • Contrast Media
  • Organotechnetium Compounds
  • Oximes
  • Serotonin Uptake Inhibitors
  • Xenon Radioisotopes
  • Technetium Tc 99m Exametazime
  • Clomipramine