Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas

Clin Exp Metastasis. 1996 May;14(3):209-14. doi: 10.1007/BF00053893.


Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P = 0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P = 0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase-pi and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis
  • Adolescent
  • Adult
  • Aged
  • Carcinoma / blood supply*
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Drug Resistance, Neoplasm
  • ErbB Receptors / biosynthesis
  • ErbB Receptors / genetics
  • Female
  • Genes, erbB-1
  • Genes, jun
  • Genes, myc
  • Glutathione Transferase / biosynthesis
  • HSP70 Heat-Shock Proteins / biosynthesis
  • Humans
  • Immunohistochemistry
  • Microcirculation
  • Middle Aged
  • Neoplasm Metastasis
  • Ovarian Neoplasms / blood supply*
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics


  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • HSP70 Heat-Shock Proteins
  • Proto-Oncogene Proteins
  • Glutathione Transferase
  • ErbB Receptors