Delay or inhibition of rat lens opacification using pantethine and WR-77913

Exp Eye Res. 1996 Jan;62(1):75-84. doi: 10.1006/exer.1996.0009.

Abstract

Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite models, each test reagent was administered 15 to 30 min prior to initiation of cataract by a single injection of Na2SeO3 or a single exposure to 15 Gy (gray) gamma radiation. In the galactose, streptozotocin and Royal College of Surgeons models where the cataractogenic insult was continuous, repeated administrations of pantethine and WR-77913 were necessary. The results suggested that protein aggregation and lens opacification associated with a variety of physiological and biochemical mechanisms can be delayed or inhibited using a systemic administration of pantethine or WR-77913.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amifostine / analogs & derivatives*
  • Amifostine / therapeutic use
  • Animals
  • Cataract / etiology
  • Cataract / pathology
  • Cataract / prevention & control*
  • Female
  • Galactose
  • Lens, Crystalline / ultrastructure
  • Male
  • Pantetheine / analogs & derivatives*
  • Pantetheine / therapeutic use
  • Protein Denaturation / drug effects
  • Radiation Injuries, Experimental / prevention & control
  • Rats
  • Rats, Sprague-Dawley
  • Sodium Selenite
  • Streptozocin

Substances

  • Pantetheine
  • WR 77913
  • Streptozocin
  • pantethine
  • Sodium Selenite
  • Amifostine
  • Galactose